Amyloidosis

Amyloidosis is a rare disease in which misfolded proteins are deposited in the body. This page mainly describes AL amyloidosis in the context of blood-related (hematological) diseases and gives you a first, briefly explained overview.

What is amyloidosis?

In amyloidosis, misfolded proteins known as amyloid are deposited in tissues and organs. In AL amyloidosis, these proteins come from abnormal plasma cells in the bone marrow. The deposits can impair the function of various organs.

Common symptoms

Possible signs can include:

• Persistent tiredness
• Fluid retention, for example in the legs
• Shortness of breath
• Numbness or tingling

These complaints can also have other causes. If symptoms persist, you should seek medical advice.

Treatment

Treatment depends on the type of amyloidosis, the organs involved and your individual situation. In AL amyloidosis, therapies aim to reduce the production of the proteins that cause the deposits, together with supportive measures for the affected organs. Your treatment plan is set individually by your care team.

Why clinical trials are important

Clinical trials help to further develop and improve treatments. Especially for rarer diseases such as amyloidosis, they can open up new options. Current clinical trials for this disease are listed below.