Research
Myeloma and AML: clues to underactive immune cells
Certain T cells in bone marrow samples recognize cancer cells but appear insufficiently activated.
A Heidelberg team examined bone marrow samples from 21 people with multiple myeloma or acute myeloid leukemia. A 15-gene signature helped distinguish tumor-reactive T cells.
DKFZ presented the findings on 10 August 2026. The signature is not a routine test. Larger prospective studies are needed, and key experiments were performed outside the body. Reliable killing of tumor cells has not yet been directly demonstrated.
Sources
- Immunzellen bei Knochenmarkkrebs: bedingt abwehrbereit (opens in a new tab) · Deutsches Krebsforschungszentrum (DKFZ) · Accessed on